- (1342-1375) Son of Alfonso XI of Castile and Leonor de Guzmán, the king's mistress.
- Brother of Enrique Count of Trastámara, and half-brother of Pedro of Castile, who persecuted him and all the Guzmán offspring.
- Married Princess Beatriz, daughter of Pedro I of Portugal and Inês de Castro, as established in the peace treaty of Santarém (1373) between Fernando of Portugal and Enrique II of Castile.
- Pedro IV of Aragon agreed to hand him over to Pedro of Castile in exchange for the Aragonese towns he had taken during his 1361 invasion of Aragon. [Pedro, ch. 32: 58-60]
- Guarantor of the Luso-Castilian Treaty of Alcoutim (1371) on behalf of his brother, Enrique II of Castile.